3,3-Dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole → 2-(3,3-Dimethyl-2,3-dihydro-1H-indol-1-yl)aniline

HRID 2192219ノート

反応式

HRID 2192219 の反応式
[CH3:1][C:2]1([CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[N+:17]([O-])=O)[CH2:3]1>CO.[Pd]>[CH3:1][C:2]1([CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[NH2:17])[CH2:3]1

参加物

4

反応物 1

HCID 593377113,3-Dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole

生成物 1

HCID 593377202-(3,3-Dimethyl-2,3-dihydro-1H-indol-1-yl)aniline収率 75%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 2d (123 mg, 0.458 mmol) in MeOH was added 10% Pd/C (20 mg). The reaction mixture was stirred at rt under H2 for 2 h. The catalyst was filtered through a cake of Celite® and the filtrate was evaporated under reduced pressure to afford 2e (80 mg, 75%) as a yellowish powder. MS (ES) m/z 239 [M+H]+.

後処理

  1. filtrationThe catalyst was filtered through a cake of Celite®
  2. customthe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-538f7a3b7f9d4d768c82be9d9ce74f7f
出典データセット
uspto-grants-2012_12
特許番号
US08329718B2

反応ノート

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