Imidazole → 5-(t-Butyldimethylsiloxy)-3-pentyne

HRID 21923

反応式

HRID 21923 の反応式
[CH2:1]([OH:5])[CH2:2][C:3]#[CH:4].[Si:6](Cl)([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7].N1C=CN=[CH:15]1>CN(C=O)C>[O:5]([CH2:1][C:2]#[C:3][CH2:4][CH3:15])[Si:6]([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7]

参加物

5

反応物 3

HCID 795ImidazoleHCID 135663-Butyn-1-OLHCID 28928tert-Butyldimethylsilyl chloride

生成物 1

HCID 110198575-(t-Butyldimethylsiloxy)-3-pentyne

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 3-butyn-1-ol (g) (10.0 g) in DMF (80 ml) were added t-butyldimethylsilyl chloride (21.5 g) and imidazol (10.6 g), and the resultant mixture was kept at 35° C. for 7 hours. The reaction mixture was treated in the conventional manner and the obtained crude product was distilled to give the title compound (h).

後処理

  1. additionThe reaction mixture was treated in the conventional manner
  2. customthe obtained crude product
  3. distillationwas distilled

出典と根拠

ORDレコード
ord-f6de6665a81f41a69e382a42c905148e
出典データセット
uspto-grants-1995_06
特許番号
US05426115

関連ノート

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