Imidazole → 5-(t-Butyldimethylsiloxy)-3-pentyne
反応式
[CH2:1]([OH:5])[CH2:2][C:3]#[CH:4].[Si:6](Cl)([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7].N1C=CN=[CH:15]1>CN(C=O)C>[O:5]([CH2:1][C:2]#[C:3][CH2:4][CH3:15])[Si:6]([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7]参加物
5
実験手順
To a solution of 3-butyn-1-ol (g) (10.0 g) in DMF (80 ml) were added t-butyldimethylsilyl chloride (21.5 g) and imidazol (10.6 g), and the resultant mixture was kept at 35° C. for 7 hours. The reaction mixture was treated in the conventional manner and the obtained crude product was distilled to give the title compound (h).
後処理
- additionThe reaction mixture was treated in the conventional manner
- customthe obtained crude product
- distillationwas distilled
出典と根拠
- ORDレコード
- ord-f6de6665a81f41a69e382a42c905148e
- 出典データセット
- uspto-grants-1995_06
- 特許番号
- US05426115
反応ノート
読み込み中…