Water → 2-Bromo-N-(6-trifluoromethyl-pyridazin-3-yl)-acetamide

HRID 2192302ノート

反応式

HRID 2192302 の反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[N:8]=[N:7][C:6]([NH2:9])=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].[Br:18][CH2:19][C:20](Br)=[O:21].O>ClCCl>[Br:18][CH2:19][C:20]([NH:9][C:6]1[N:7]=[N:8][C:3]([C:2]([F:1])([F:10])[F:11])=[CH:4][CH:5]=1)=[O:21]

参加物

6

反応物 4

HCID 962Water2 回HCID 11430Potassium CarbonateHCID 61147Bromoacetyl bromideHCID 598058596-(Trifluoromethyl)pyridazin-3-amine

生成物 1

HCID 670277332-Bromo-N-(6-trifluoromethyl-pyridazin-3-yl)-acetamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

6-Trifluoromethyl-pyridazin-3-ylamine (0.042 g) (prepared by a procedure similar to that described in WO2007048779) was dissolved in dichloromethane (40 mL) and stirred with potassium carbonate (0.214 g). 2-Bromoacetyl bromide (0.12 mL) was added and stirring continued for 1.5 hours. Water (0.24 mL) was added and the reaction mixture was stirred for 1.5 hours after which water (40 mL) was added and the reaction mixture stirred for a further 1.5 hours. The dichloromethane was separated, dried (MgSO4) and evaporated to afford the sub-titled compound as a white solid (0.053 g).

後処理

  1. additionwas added
  2. stirringthe reaction mixture stirred for a further 1.5 hours
  3. customThe dichloromethane was separated
  4. dry with materialdried (MgSO4)
  5. customevaporated

出典と根拠

ORDレコード
ord-79a9d785de3d43c5ac5f844ce979c38f
出典データセット
uspto-grants-2012_12
特許番号
US08329729B2

反応ノート

読み込み中…