2-Methylpentane → HCID 86655271、化合物

HRID 2192313ノート

反応式

HRID 2192313 の反応式
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10]([C:12]1([C:19]3[S:20][CH:21]=[CH:22][CH:23]=3)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:11])[CH2:2]2.[Br:24][CH2:25][C:26]([NH:28][C:29]1[O:33][N:32]=[C:31]([CH3:34])[CH:30]=1)=[O:27].C(OCC)(=O)C.CCCC(C)C>C(#N)C>[Br-:24].[CH3:34][C:31]1[CH:30]=[C:29]([NH:28][C:26]([CH2:25][N+:1]23[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8]2)[C@@H:3]([O:9][C:10]([C:12]2([C:19]4[S:20][CH:21]=[CH:22][CH:23]=4)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:11])[CH2:2]3)=[O:27])[O:33][N:32]=1

参加物

6

反応物 4

HCID 78922-MethylpentaneHCID 8857Ethyl AcetateHCID 133629642-Bromo-N-(3-methylisoxazol-5-yl)acetamideHCID 58348375HCID 58348375、化合物

生成物 1

HCID 86655271HCID 86655271、化合物収率 45.8%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

1-Thiophen-2-yl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 5d) (50 mg) and 2-bromo-N-(3-methylisoxazol-5-yl)acetamide (Example 7a) (32 mg) were dissolved in acetonitrile (2 mL) and left overnight. Ethyl acetate (10 mL) and isohexane (10 mL) were added and the crystals filtered off, washed with ethyl acetate and dried to afford the titled compound (37 mg).

後処理

  1. filtrationthe crystals filtered off
  2. washwashed with ethyl acetate
  3. customdried

出典と根拠

ORDレコード
ord-85ed8045569a4562a5af4971a8928d67
出典データセット
uspto-grants-2012_12
特許番号
US08329729B2

反応ノート

読み込み中…