Diethyl Ether → HCID 86655279、化合物

HRID 2192340ノート

反応式

HRID 2192340 の反応式
[Cl:1][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][N:7]=1)=[O:4].[N:13]12[CH2:20][CH2:19][CH:16]([CH2:17][CH2:18]1)[C@@H:15]([O:21][C:22]([C:24]1([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1)=[O:23])[CH2:14]2.C(OCC)C>C(#N)C>[Cl-:1].[F:12][C:9]1[CH:10]=[CH:11][C:6]([NH:5][C:3]([CH2:2][N+:13]23[CH2:20][CH2:19][CH:16]([CH2:17][CH2:18]2)[C@@H:15]([O:21][C:22]([C:24]2([C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)=[O:23])[CH2:14]3)=[O:4])=[N:7][CH:8]=1

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 229347512-Chloro-N-(5-fluoro-2-pyridinyl)acetamideHCID 591796191-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

生成物 1

HCID 86655279HCID 86655279、化合物収率 63.5%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2-Chloro-N-(5-fluoro-pyridin-2-yl)-acetamide (Example 17a) (31 mg) was added to a solution of 1-phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 14e) (49 mg) in acetonitrile (1 mL). The reaction mixture was stirred at room temperature overnight. Diethyl ether (2 mL) was added to the reaction mixture and the white solid was filtered off, washed several times with diethyl ether and dried under vacuum at 40° C. to give the title compound (49 mg).

後処理

  1. filtrationthe white solid was filtered off
  2. washwashed several times with diethyl ether
  3. customdried under vacuum at 40° C.

出典と根拠

ORDレコード
ord-801a3f4be019424b827905f4d72f6fe3
出典データセット
uspto-grants-2012_12
特許番号
US08329729B2

反応ノート

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