Water → 2-bromo-N-(2,6-difluorophenyl)acetamide
反応式
[F:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([F:9])[C:3]=1[NH2:4].C(=O)([O-])[O-].[K+].[K+].[Br:16][CH2:17][C:18](Br)=[O:19].O>ClCCl>[Br:16][CH2:17][C:18]([NH:4][C:3]1[C:2]([F:1])=[CH:8][CH:7]=[CH:6][C:5]=1[F:9])=[O:19]参加物
6
実験手順
To a mixture of 2,6-difluoroaniline (1.12 g) and potassium carbonate (1.8 g) in 50 mL dichloromethane was added bromoacetyl bromide (1.5 mL) and the mixture was stirred at room temperature for 17 h. Water was added and the mixture stirred for several hours then the phases were separated on a hydrophobic frit and the organic layer was evaporated. The crude product was purified by silica gel chromatography eluting with 0-100% EtOAc/cyclohexane to give the sub-titled compound (0.92 g) as a white solid.
後処理
- stirringthe mixture stirred for several hours
- customthe phases were separated on a hydrophobic frit
- customthe organic layer was evaporated
- customThe crude product was purified by silica gel chromatography
- washeluting with 0-100% EtOAc/cyclohexane
出典と根拠
- ORDレコード
- ord-8890ce025c234df4bdf6c63ff5005ddb
- 出典データセット
- uspto-grants-2012_12
- 特許番号
- US08329729B2
反応ノート
読み込み中…