N-(3-Bromopropyl)-2-pyridinecarboxamide → HCID 67311727、化合物

HRID 2192393ノート

反応式

HRID 2192393 の反応式
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10]([C:12]1([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:11])[CH2:2]2.[Br:25][CH2:26][CH2:27][CH2:28][NH:29][C:30]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=1)=[O:31]>CC#N>[Br-:25].[C:19]1([C:12]2([C:10]([O:9][C@@H:3]3[CH:4]4[CH2:7][CH2:8][N+:1]([CH2:26][CH2:27][CH2:28][NH:29][C:30]([C:32]5[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=5)=[O:31])([CH2:6][CH2:5]4)[CH2:2]3)=[O:11])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

参加物

4

反応物 2

HCID 12983474N-(3-Bromopropyl)-2-pyridinecarboxamideHCID 591796191-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

生成物 1

HCID 67311727HCID 67311727、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

1-Phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Example 14e) (0.31 mmol) and pyridine-2-carboxylic acid (3-bromo-propyl)-amide (Example 57b (0.31 mmol) were stirred together in anhydrous MeCN (3 mL) at room temperature for 16 days. The reaction mixture was concentrated in vacuo and the solid purified by silica gel chromatography eluting with 0-15% MeOH/dichloromethane to give the title compound (145 mg) as a white solid.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe solid purified by silica gel chromatography
  3. washeluting with 0-15% MeOH/dichloromethane

出典と根拠

ORDレコード
ord-8ef825ce5bf842b1abd58f8579edf26c
出典データセット
uspto-grants-2012_12
特許番号
US08329729B2

反応ノート

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