Dimethylformamide → 3-Chloro-4-[(difluoromethyl)oxy]benzoyl chloride
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH:12]([F:14])[F:13])[C:5](O)=[O:6].C(Cl)(=O)C([Cl:18])=O.CN(C)C=O>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH:12]([F:14])[F:13])[C:5]([Cl:18])=[O:6]参加物
5
実験手順
3-Chloro-4-[(difluoromethyl)oxy]benzoic acid (D17; 0.28 g, 1.258 mmol) was stirred at room temperature with oxalyl chloride (0.220 mL, 2.52 mmol) and N,N-dimethylformamide (DMF) (0.05 ml) in dry dichloromethane (DCM) (5 ml) under nitrogen for 16 h. The solvent was evaporated in vacuo to give a yellow semi-solid (380 mg) which was used crude in the subsequent reaction D47.
後処理
- customThe solvent was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-65426e63b3224c6a8ff4f11149b4bb70
- 出典データセット
- uspto-grants-2012_12
- 特許番号
- US08329730B2
反応ノート
読み込み中…