Dimethylformamide → 3-Cyano-4-[(cyclopropylmethyl)oxy]benzoyl chloride
反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[C:7]([C:9]1[CH:10]=C([CH:15]=[CH:16][C:17]=1[O:18][CH2:19][CH:20]1[CH2:22][CH2:21]1)C(O)=O)#[N:8].CN(C)C=O>ClCCl>[C:7]([C:9]1[CH:10]=[C:1]([CH:15]=[CH:16][C:17]=1[O:18][CH2:19][CH:20]1[CH2:22][CH2:21]1)[C:2]([Cl:4])=[O:3])#[N:8]参加物
5
実験手順
Oxalyl chloride (0.040 ml, 0.460 mmol) was added to a stirred solution of 3-cyano-4-[(cyclopropylmethyl)oxy]benzoic acid (D24; 50 mg, 0.230 mmol) in dichloromethane (DCM) (2 ml) containing N,N-dimethylformamide (DMF) (0.02 ml) at room temperature under nitrogen, and the mixture was stirred at room temperature for 2 h. The solvent was evaporated in vacuo to give the title compound (54.2 mg) which was used in the subsequent step (D49) without purification.
後処理
- customThe solvent was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-1dac3804346d462588f7baebeedbc12d
- 出典データセット
- uspto-grants-2012_12
- 特許番号
- US08329730B2
反応ノート
読み込み中…