Methanol → HCID 17786435、化合物
反応式
[N:1]([CH:4]([C:7]1[CH:12]=[N:11][CH:10]=[CH:9][N:8]=1)[CH2:5][CH3:6])=[N+]=[N-].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.CO>C1COCC1.O>[N:8]1[CH:9]=[CH:10][N:11]=[CH:12][C:7]=1[CH:4]([NH2:1])[CH2:5][CH3:6]参加物
6
反応条件
- 温度
- 50 °C
実験手順
The 2-(1-azidopropyl)pyrazine (56 mg) was dissolved in the THF (5 ml) and water (1 ml) and the PS-PPh3 (225 mg) added. The reaction mixture was heated to 50° C. and left to stir for approx. 20 hours. The mixture was filtered under vacuum and rinsed with DCM (a precipitate formed and re-dissolved with MeOH) then MeOH. The filtrate was evaporated to yield the title compound as a yellow oil which was used without further purification. [M+H]+ 138.
後処理
- waitleft
- filtrationThe mixture was filtered under vacuum
- washrinsed with DCM (a precipitate
- customformed
- customThe filtrate was evaporated
出典と根拠
- ORDレコード
- ord-d83c63f93c4d428eb66885038a014cfa
- 出典データセット
- uspto-grants-2012_12
- 特許番号
- US08329754B2
反応ノート
読み込み中…