Methanol → ethyl 2-(5-oxo-1,6-naphthyridin-6(5H)-yl)acetate
反応式
[N:1]1[C:10]2[CH:9]=[CH:8][N:7]=[C:6]([OH:11])[C:5]=2[CH:4]=[CH:3][CH:2]=1.I[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15].C(=O)([O-])[O-].[Cs+].[Cs+].CO>C1COCC1>[O:11]=[C:6]1[N:7]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:8]=[CH:9][C:10]2[N:1]=[CH:2][CH:3]=[CH:4][C:5]1=2参加物
6
反応条件
- 温度
- 100 °C
実験手順
1,6-naphthyridin-5-ol (1.00 g, 6.8 mmol), ethyl iodoacetate (1.6 ml, 14 mmol) and cesium carbonate (4.5 g, 14 mmol) were dissolved in 25 mL of THF then stirred and heated at 100° C. for 2 h until the reaction was complete. The reaction was concentrated and purified via MPLC using a gradient to 90% DCM: 10% MeOH to afford ethyl 2-(5-oxo-1,6-naphthyridin-6(5H)-yl)acetate (1.5 g, 94% yield).
後処理
- concentrationThe reaction was concentrated
- custompurified via MPLC
出典と根拠
- ORDレコード
- ord-e4ccbd0856c048dba118d4c56b7c5abe
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08198448B2
反応ノート
読み込み中…