Hydrogen chloride-ethyl acetate → HCID 67539358、化合物

HRID 2193342

反応式

HRID 2193342 の反応式
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8](=[O:30])[N:9]2[CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([NH:20][CH2:21][C:22]#[C:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:16][CH2:15]2)=[CH:4][CH:3]=1.[ClH:31].C(OCC)(=O)C>C(Cl)(Cl)Cl>[ClH:31].[F:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8](=[O:30])[N:9]2[CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([NH:20][CH2:21][C:22]#[C:23][C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH2:18][CH2:19]2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 593980247-fluoro-1-(2-(4-(3-phenyl-2-propyn-1-ylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one

生成物 1

HCID 67539358HCID 67539358、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To 10 mL of a chloroform solution containing 209 mg of 7-fluoro-1-(2-(4-(3-phenyl-2-propyn-1-ylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature for 10 min. The solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 197 mg of 7-fluoro-1-(2-(4-(3-phenyl-2-propyn-1-ylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride as a pale brown solid.

後処理

  1. additionwas added
  2. customThe solvent was removed under reduced pressure, ethyl acetate
  3. additionwas added
  4. filtrationthe resulting solid was filtered

出典と根拠

ORDレコード
ord-e541995859804e65b47094544d5097e6
出典データセット
uspto-grants-2012_12
特許番号
US08329694B2

関連ノート

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