Hydrogen chloride-ethyl acetate → HCID 67537667、化合物

HRID 2193343

反応式

HRID 2193343 の反応式
[C:1]1([C:7]#[C:8][CH2:9][N:10]([CH2:31][C:32]#[C:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][N:19]3[C:28]4[C:23](=[CH:24][CH:25]=[C:26]([F:29])[CH:27]=4)[N:22]=[CH:21][C:20]3=[O:30])[CH2:13][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:40].C(OCC)(=O)C>C(Cl)(Cl)Cl>[ClH:40].[C:34]1([C:33]#[C:32][CH2:31][N:10]([CH2:9][C:8]#[C:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][N:19]3[C:28]4[C:23](=[CH:24][CH:25]=[C:26]([F:29])[CH:27]=4)[N:22]=[CH:21][C:20]3=[O:30])[CH2:13][CH2:12]2)[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

参加物

4

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 593983021-(2-(4-(bis(3-phenyl-2-propyn-1-yl)amino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one

生成物 1

HCID 67537667HCID 67537667、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To 5 mL of a chloroform solution containing 132 mg of 1-(2-(4-(bis(3-phenyl-2-propyn-1-yl)amino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one, 0.5 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature for 10 min. The solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 141 mg of 1-(2-(4-(bis(3-phenyl-2-propyn-1-yl)amino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one hydrochloride as a pale brown solid.

後処理

  1. additionwas added
  2. customThe solvent was removed under reduced pressure, ethyl acetate
  3. additionwas added
  4. filtrationthe resulting solid was filtered

出典と根拠

ORDレコード
ord-306bc89b724645a7bd1a69977342657e
出典データセット
uspto-grants-2012_12
特許番号
US08329694B2

関連ノート

読み込み中…