Hydrogen chloride-ethyl acetate → HCID 67539252、化合物

HRID 2193345

反応式

HRID 2193345 の反応式
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8](=[O:32])[N:9]2[CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([NH:20][CH2:21][C:22]3[CH:26]=[C:25]([C:27]4[S:28][CH:29]=[CH:30][CH:31]=4)[O:24][N:23]=3)[CH2:16][CH2:15]2)=[CH:4][CH:3]=1.[ClH:33].C(OCC)(=O)C>C(Cl)(Cl)Cl>[ClH:33].[F:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8](=[O:32])[N:9]2[CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([NH:20][CH2:21][C:22]3[CH:26]=[C:25]([C:27]4[S:28][CH:29]=[CH:30][CH:31]=4)[O:24][N:23]=3)[CH2:18][CH2:19]2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 593983557-fluoro-1-(2-(4-((5-(thiophen-2-yl)isoxazol-3-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one

生成物 1

HCID 67539252HCID 67539252、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To 10 mL of a chloroform solution containing 232 mg of 7-fluoro-1-(2-(4-((5-(thiophen-2-yl)isoxazol-3-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature for 10 min. The solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 247 mg of 7-fluoro-1-(2-(4-((5-(thiophen-2-yl)isoxazol-3-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride as a pale brown solid.

後処理

  1. additionwas added
  2. customThe solvent was removed under reduced pressure, ethyl acetate
  3. additionwas added
  4. filtrationthe resulting solid was filtered

出典と根拠

ORDレコード
ord-d60dc14f45124801bd87704b1f769f3b
出典データセット
uspto-grants-2012_12
特許番号
US08329694B2

関連ノート

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