Benzene, 1-iodo-4-(trifluoromethyl)- → 8-(3,5-Dimethyl-isoxazole-4-sulfonyl)-2-(4-trifluoromethyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

HRID 2194145

反応式

HRID 2194145 の反応式
[CH3:1][C:2]1[C:6]([S:7]([N:10]2[CH2:20][CH2:19][C:13]3([C:17](=[O:18])[NH:16][CH2:15][CH2:14]3)[CH2:12][CH2:11]2)(=[O:9])=[O:8])=[C:5]([CH3:21])[O:4][N:3]=1.I[C:23]1[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=1>>[CH3:1][C:2]1[C:6]([S:7]([N:10]2[CH2:11][CH2:12][C:13]3([C:17](=[O:18])[N:16]([C:23]4[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=4)[CH2:15][CH2:14]3)[CH2:19][CH2:20]2)(=[O:9])=[O:8])=[C:5]([CH3:21])[O:4][N:3]=1

参加物

3

反応物 2

HCID 67993Benzene, 1-iodo-4-(trifluoromethyl)-HCID 595779008-(3,5-Dimethyl-isoxazole-4-sulfonyl)-2,8-diaza-spiro[4.5]decan-1-one

生成物 1

HCID 595779208-(3,5-Dimethyl-isoxazole-4-sulfonyl)-2-(4-trifluoromethyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

実験手順

This material was prepared according to example 162 step B) from 8-(3,5-dimethyl-isoxazole-4-sulfonyl)-2,8-diaza-spiro[4.5]decan-1-one and 1-iodo-4-trifluoromethyl-benzene. Off white solid. MS (ESI): 458.13 MH+).

後処理

  1. customThis material was prepared

出典と根拠

ORDレコード
ord-45d7240adedc49e6b7f52eee18687476
出典データセット
uspto-grants-2012_12
特許番号
US08329904B2

関連ノート

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