1-Cyanomethyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester → Tetrahydro-pyrrolo[1,2-a]pyrazine-1,6-dione

HRID 2194360ノート

反応式

HRID 2194360 の反応式
C[O:2][C:3]([CH:5]1[CH2:9][CH2:8][C:7](=[O:10])[N:6]1[CH2:11][C:12]#[N:13])=O>CO.O=[Pt]=O>[C:3]1(=[O:2])[NH:13][CH2:12][CH2:11][N:6]2[C:7](=[O:10])[CH2:8][CH:9]=[C:5]12

参加物

4

反応物 1

HCID 866498781-Cyanomethyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester

生成物 1

HCID 66867679Tetrahydro-pyrrolo[1,2-a]pyrazine-1,6-dione収率 63.1%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 887Methanol溶媒

実験手順

1-Cyanomethyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester (1.1 g, 6.04 mmol) was dissolved in MeOH (30 ml) and hydrogenated over PtO2 (200 mg) at 20 psi for 24 hours. After filtration of the catalyst, the solvent was removed under vacuum and the residue triturated with iPrOH to afford the title compound as a white powder (580 mg, 62% yield).

後処理

  1. filtrationAfter filtration of the catalyst
  2. customthe solvent was removed under vacuum
  3. customthe residue triturated with iPrOH

出典と根拠

ORDレコード
ord-a6b0968dc79a478b84af28cbee335112
出典データセット
uspto-grants-2012_12
特許番号
US08334286B2

反応ノート

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