(2-Anilinopyridin-3-yl)methanol → HCID 13983610、化合物

HRID 2194526ノート

反応式

HRID 2194526 の反応式
[C:1]1([NH:7][C:8]2[C:13]([CH2:14][OH:15])=[CH:12][CH:11]=[CH:10][N:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[C:1]1([NH:7][C:8]2[N:9]=[CH:10][CH:11]=[CH:12][C:13]=2[CH:14]=[O:15])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 1

HCID 13986159(2-Anilinopyridin-3-yl)methanol

生成物 1

HCID 13983610HCID 13983610、化合物収率 104.7%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

反応条件

温度
60 °C

実験手順

6.35 g (31.7 mmol) of (2-phenylamino-3-pyridinyl)methanol was dissolved in chloroform (100 mL), and 8.27 g (95.1 mmol) of manganese dioxide was added thereto. The resulting mixture was stirred for 7 hours at 60° C. The reaction mixture was filtered, and the filtrate was concentrated. Thus, 6.58 g of the title compound was obtained as an orange-colored solid (yield: quantitative).

後処理

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-6eb5ed50435d4adc87613fed18464197
出典データセット
uspto-grants-2012_12
特許番号
US08334236B2

反応ノート

読み込み中…