Trifluoroacetic acid → HCID 178461297、化合物
反応式
[Br:1][C:2]1[C:3]([O:16][CH:17]2[CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18]2)=[N:4][C:5]([NH:8][C@H:9]2[CH2:14][CH2:13][C@@H:12]([CH3:15])[CH2:11][CH2:10]2)=[N:6][CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH:19]1[CH2:18][CH:17]([O:16][C:3]2[C:2]([Br:1])=[CH:7][N:6]=[C:5]([NH:8][C@H:9]3[CH2:14][CH2:13][C@@H:12]([CH3:15])[CH2:11][CH2:10]3)[N:4]=2)[CH2:20]1参加物
4
実験手順
To tert-butyl 3-(5-bromo-2-(cis-4-methylcyclohexylamino)pyrimidin-4-yloxy)azetidine-1-carboxylate (6.5 g, 14 mmol) in DCM (25 mL) was added TFA (4 mL). The mixture was stirred at room temperature for 4 h, diluted with DCM, washed with 1N NaOH solution, water, dried over sodium sulfate, filtered and concentrated to dryness. MS (ESI) m/z Calc. 340.1 (M+). Found: 342.1 (M++2).