Hydrogen Bromide → 2-bromo-5-chloro-1,3-dimethylbenzene

To an initial charge of 65 ml of 48% aqueous HBr are added, in portions, 15.56 g [0.1 mol] of 4-chloro-2,6-dimethylaniline. The resulting thick suspension is stirred at 80° C. for 15 minutes. It is then cooled to −10° C., and a solution of 8 g [0.116 mol] of NaNO2 in 35 ml of water is added dropwise within approx. 40 minutes at such a rate that the temperature does not exceed −5° C. 80 mg of sulphamic acid are added. Then the suspension of the diazonium salt cooled to −10° C. is metered within about 25 minutes into a solution, heated to 80° C., of 28.6 g [0.103 mol] of FeSO4×7H20 in 65 ml of 62% aqueous HBr. The reaction mixture is then stirred at 80° C. for another 1 hour, allowed to cool to room temperature and admixed with 125 ml of water, the phases are separated and the aqueous phase is extracted three times with 50 ml each time of methylene chloride. The combined organic phases are washed twice with 25 ml each time of water, dried and concentrated under reduced pressure. This gives 17.2 g of an oil which, according to GC, contains 95.6% 4-chloro-2,6-dimethylbromobenzene (75% of theory).

1. temperatureIt is then cooled to −10° C.
2. customdoes not exceed −5° C
3. temperaturecooled to −10° C.
4. waitis metered within about 25 minutes into a solution
5. stirringThe reaction mixture is then stirred at 80° C. for another 1 hour
6. temperatureto cool to room temperature
7. customthe phases are separated
8. extractionthe aqueous phase is extracted three times with 50 ml each time of methylene chloride
9. washThe combined organic phases are washed twice with 25 ml each time of water
10. customdried
11. concentrationconcentrated under reduced pressure

ORDレコード

ord-a4a82bce4fd845a8b5a4f3c0e62479d1

出典データセット

uspto-grants-2012_12

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08334417B2