Cyclohexene → 2-amino-5-(2,6-dimethyl-4-morpholinyl)Benzoic acid
反応式
[N+:1]([C:4]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:18][CH:17]([CH3:19])[O:16][CH:15]([CH3:20])[CH2:14]2)=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-])=O.C1CCCCC=1>[Pd]>[NH2:1][C:4]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:18][CH:17]([CH3:19])[O:16][CH:15]([CH3:20])[CH2:14]2)=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]参加物
4
実験手順
The mixture of 6 g 2-nitro-5-(2,6-dimethylmorpholin-4-yl)benzoic acid, 15 ml cyclohexene and 3 g Pd/C (10%) is heated under reflux for 6 hours. The hot reaction mixture is filtered through a celite pad. After evaporation of the filtrate 4.8 g title product is obtained (MH+: 251).
後処理
- temperatureis heated
- temperatureunder reflux for 6 hours
- filtrationThe hot reaction mixture is filtered through a celite pad
- customAfter evaporation of the filtrate 4.8 g title product
- customis obtained (MH+: 251)
出典と根拠
- ORDレコード
- ord-433cddb174df4f15ace534a9d53a86bf
- 出典データセット
- uspto-grants-2012_12
- 特許番号
- US08338411B2
反応ノート
読み込み中…