Lithium Hydroxide → 2-(Pyridin-4-yl)pyrimidine-5-carboxylic acid

HRID 219639

反応式

HRID 219639 の反応式
C[O:2][C:3]([C:5]1[CH:6]=[N:7][C:8]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)=[N:9][CH:10]=1)=[O:4].[Li+].[OH-]>CO>[N:14]1[CH:15]=[CH:16][C:11]([C:8]2[N:7]=[CH:6][C:5]([C:3]([OH:4])=[O:2])=[CH:10][N:9]=2)=[CH:12][CH:13]=1

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 69122655Methyl 2-(pyridin-4-yl)pyrimidine-5-carboxylate

生成物 1

HCID 227102132-(Pyridin-4-yl)pyrimidine-5-carboxylic acid収率 96%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 2-pyridin-4-yl-pyrimidine-5-carboxylic acid methyl ester (1.11 g, 5.18 mmol), and aqueous LiOH (1 M, 5.18 mL) in MeOH (7.25 mL) is stirred at room temperature overnight. MeOH is removed in vacuo, and the aqueous solution is treated with 3 N HCl to adjust the pH to between 2 and 3. The solid is filtered off and washed with water and dried in vacuum to yield 2-pyridin-4-yl-pyrimidine-5-carboxylic acid (1 g, 96%) as a solid. MS: 202 (M+H).

後処理

  1. customMeOH is removed in vacuo
  2. additionthe aqueous solution is treated with 3 N HCl
  3. filtrationThe solid is filtered off
  4. washwashed with water
  5. customdried in vacuum

出典と根拠

ORDレコード
ord-491d2d1456254b5c9f5411093db16779
出典データセット
uspto-grants-2012_06
特許番号
US08202863B2

関連ノート

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