Sodium borohydride → (2-Bromo-6-fluorophenyl)methanol

HRID 2196457ノート

反応式

HRID 2196457 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH2:4][OH:5]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 224739772-Bromo-6-fluorobenzaldehyde

生成物 1

HCID 44181801(2-Bromo-6-fluorophenyl)methanol収率 89.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

20.0 g (0098 mol) of 2-bromo-6-fluorobenzaldehyde are dissolved in 500 ml of methanol and cooled in an ice bath; 3.72 g (0.098 mol) of sodium borohydride are then added thereto, portionwise. The mixture is stirred under cold conditions for 1 hour and the solvent is then evaporated off under reduced pressure. The residue is taken up between water and dichloromethane, and the organic phase is separated, dried and concentrated under reduced pressure. The residue is crystallized from pentane. 18.1 g of compound are obtained.

後処理

  1. temperaturecooled in an ice bath
  2. customthe solvent is then evaporated off under reduced pressure
  3. customthe organic phase is separated
  4. customdried
  5. concentrationconcentrated under reduced pressure
  6. customThe residue is crystallized from pentane

出典と根拠

ORDレコード
ord-3b776c9206ec4bdf9851abee129f4ea4
出典データセット
uspto-grants-2012_12
特許番号
US08338451B2

反応ノート

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