benzyl 4-(6-(2-methoxybenzyl)-4-methyl-7-oxo-3-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo[3,4-d]pyridazin-1-yl)piperidine-1-carboxylate → 6-(2-methoxybenzyl)-4-methyl-1-(piperidin-4-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyridazin-7(6H)-one
反応式
[CH3:1][O:2][C:3]1[CH:40]=[CH:39][CH:38]=[CH:37][C:4]=1[CH2:5][N:6]1[C:11](=[O:12])[C:10]2[N:13]([CH:20]3[CH2:25][CH2:24][N:23](C(OCC4C=CC=CC=4)=O)[CH2:22][CH2:21]3)[N:14]=[C:15]([C:16]([F:19])([F:18])[F:17])[C:9]=2[C:8]([CH3:36])=[N:7]1>CCO.[Pd]>[CH3:1][O:2][C:3]1[CH:40]=[CH:39][CH:38]=[CH:37][C:4]=1[CH2:5][N:6]1[C:11](=[O:12])[C:10]2[N:13]([CH:20]3[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]3)[N:14]=[C:15]([C:16]([F:17])([F:18])[F:19])[C:9]=2[C:8]([CH3:36])=[N:7]1参加物
4
反応物 1
生成物 1
試薬・触媒・溶媒 2
実験手順
To a stirred solution of 113 (81 mg, 0.146 mmol) in EtOH (1.5 mL) was added Pd/C (10% Degussa type, 15.5 mg, 0.015 mmol). The resulting suspension was allowed to stir for 30 min at room temperature under latm of H2 gas. The catalyst was filtrate over Celite and the solvent was evaporated to give crude 114. LRMS (ESI): calc. 421.4; found 422.3 (MH)+.