Trifluoroacetic acid → Pyrrolidine-2-carbaldehyde-O-benzyl-oxime
反応式
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[CH:13]=[N:14][O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH2:16]([O:15][N:14]=[CH:13][CH:9]1[CH2:10][CH2:11][CH2:12][NH:8]1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1参加物
4
実験手順
The solution of 2-(benzyloxyimino-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (1.50 g, 4.92 mmole) and TFA (10 ml) in dichloromethane (10 ml) is stirred for 2 hours at room temperature. Solvent is removed. The crude product is carried to next step without further purification. M+H+=205.1
後処理
- customSolvent is removed
- customThe crude product is carried to next step without further purification
出典と根拠
- ORDレコード
- ord-50bb8ff78e8e4f5394481339688439a5
- 出典データセット
- uspto-grants-2012_12
- 特許番号
- US08338440B2
反応ノート
読み込み中…