Water → (R)-(-)-1-acetoxy-3-bromo-2-methyl-propane

HRID 219708

反応式

HRID 219708 の反応式
[Br:1][CH2:2][C@H:3]([CH3:6])[CH2:4][OH:5].[C:7](OC(=O)C)(=[O:9])[CH3:8].O.C(OCC)(=O)C>N1C=CC=CC=1>[C:7]([O:5][CH2:4][C@@H:3]([CH3:6])[CH2:2][Br:1])(=[O:9])[CH3:8]

参加物

6

反応物 4

HCID 962WaterHCID 7918Acetic AnhydrideHCID 8857Ethyl AcetateHCID 10441885(R)-(-)-3-Bromo-2-methyl-1-propanol

生成物 1

HCID 10420167(R)-(-)-1-acetoxy-3-bromo-2-methyl-propane収率 78.9%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
70 °C

実験手順

6 g of (R)-(−)-3-bromo-2-methyl-1-propanol (39.2 mmol) were stirred in 6 ml of pyridine at room temperature. 4.08 g of acetic anhydride (43.1 mmol) were added and the reaction mixture was stirred for 4 h at 70° C. Stirring was continued for 16 h at room temperature. 40 ml of water and 60 ml of ethyl acetate were added to the reaction mixture. The organic layer was separated and washed with a further portion of water, then dried over magnesium sulfate, filtered, and evaporated under vacuum, whereby 6.03 g of the title compound were obtained.

後処理

  1. stirringStirring
  2. waitwas continued for 16 h at room temperature
  3. customThe organic layer was separated
  4. washwashed with a further portion of water
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. customevaporated under vacuum

出典と根拠

ORDレコード
ord-6f9dc5e1502d4ada80fbc8054545cf17
出典データセット
uspto-grants-2012_06
特許番号
US08202868B2

関連ノート

読み込み中…