化工社化工社 化学情報印刷レポート · 研究参考用
Cyanoacetic acid → (1-Ethyl-1,2,3,6-tetrahydropyrid-4-yl)acetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyanoacetic acid | HCID 9740 | — |
| 反応物 | 1-Ethylpiperidin-4-one | HCID 77159 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | (1-Ethyl-1,2,3,6-tetrahydropyrid-4-yl)acetonitrile | HCID 66602178 | 122.6% |
反応手順
2.9 g of 1-ethyl-4-piperidone, 3.3 g of cyanoacetic acid and 36 ml of toluene are placed in a round-bottomed flask equipped with a magnetic stirrer, and under a stream of nitrogen. The mixture is refluxed for 4 hours, while removing the water using Markusson apparatus. The solvent is evaporated off under vacuum. 4.2 g of oil are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08202871B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-9a34e0d9277f498ebb1ff39c1fbc7ffc |
| 出典メモ | uspto-grants-2012_06 |