Salicyl Alcohol → 2-[(Ethylsulfanyl)methyl]phenol
反応式
O[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9].[CH2:10]([SH:12])[CH3:11]>ClC1C=CC=CC=1Cl>[CH2:10]([S:12][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9])[CH3:11]参加物
4
実験手順
A mixture of 49.6 g (0.4 mol) of 2-hydroxymethyl-phenol, 24.8 g (0.4 mol) of ethylmercaptan and 200 ml of o-dichlorobenzene was heated in a flask equipped with a stirrer and a reflux condenser, under normal pressure, and starting from room temperature, in such a way that there was always a moderate reflux and that the final temperature in the flask did not exceed about 125° C. In total, the mixture was heated under reflux for about 20 hours. Thereafter, working up by distillation gave 2-ethylthiomethyl-phenol in a yield of 87% of theory. The o-dichlorobenzene distilled off could be re-used in a subsequent batch.
後処理
- temperaturewas heated in a flask
- customequipped with a stirrer and a reflux condenser, under normal pressure
- customstarting from room temperature
- temperaturea moderate reflux
- customdid not exceed about 125° C
- temperatureIn total, the mixture was heated
- temperatureunder reflux for about 20 hours
- distillationThereafter, working up by distillation
出典と根拠
- ORDレコード
- ord-85871db35598409f84503505060a132e
- 出典データセット
- uspto-grants-1982_11
- 特許番号
- US04358616
反応ノート
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