Methyl 2-fluoro-5-methoxy-4-nitrobenzoate → Methyl 4-amino-2-fluoro-5-methoxybenzoate
反応式
[F:1][C:2]1[CH:11]=[C:10]([N+:12]([O-])=O)[C:9]([O:15][CH3:16])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]>CO.[Pd]>[NH2:12][C:10]1[C:9]([O:15][CH3:16])=[CH:8][C:3]([C:4]([O:6][CH3:7])=[O:5])=[C:2]([F:1])[CH:11]=1参加物
4
実験手順
Methyl 2-fluoro-5-methoxy-4-nitrobenzoate (549 mg; 1.13 mmol; 1 eq.) was dissolved in MeOH (50 mL). The resulting solution was injected on a flow hydrogenation reactor (H-Cube), adapted with Pd/C cartridge (44 mm), a flow of 1 mL/min, a temperature of 60° C. and the full H2 option enabled. Solvents were evaporated, affording the title product as an off-white solid (220 mg; 97%). LC/MS (Method B): 200.0 (M+H)+. HPLC (Method A) Rt 3 min (Purity: 91.9%).
後処理
- customThe resulting solution was injected on a flow hydrogenation reactor
- customa temperature of 60° C.
- customSolvents were evaporated
出典と根拠
- ORDレコード
- ord-dc4443a2126b496988c907898b32512d
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08202865B2
反応ノート
読み込み中…