Sodium Iodide → t-Butyl methyl 7-iodoheptylmalonate

HRID 21987

反応式

HRID 21987 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]([C:17]([O:19][CH3:20])=[O:18])[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11].[I-:21].[Na+]>CC(C)=O>[I:21][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]([C:17]([O:19][CH3:20])=[O:18])[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11]

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 19930816t-Butyl methyl 7-bromoheptylmalonate

生成物 1

HCID 19930825t-Butyl methyl 7-iodoheptylmalonate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

t-Butyl methyl 7-bromoheptylmalonate (8.81 g, 25.1 mmol) is dissolved in acetone (50 ml). Sodium iodide (3.7 g, 25.1 mmol) is added and the mixture is stirred at reflux for 2 hours. The reaction mixture is filtered and the filtrate is concentrated to dryness. The residue is dissolved in methylene chloride and filtered again. The filtrate is concentrated to dryness to give t-butyl methyl 7-iodoheptylmalonate as an oil.

後処理

  1. temperatureat reflux for 2 hours
  2. filtrationThe reaction mixture is filtered
  3. concentrationthe filtrate is concentrated to dryness
  4. dissolutionThe residue is dissolved in methylene chloride
  5. filtrationfiltered again
  6. concentrationThe filtrate is concentrated to dryness

出典と根拠

ORDレコード
ord-b8ac2a8fbbd24551a35842c1f9e8fd6a
出典データセット
uspto-grants-1995_06
特許番号
US05426103

関連ノート

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