Acetonitrile → HCID 12899882、化合物
反応式
[F:1][CH2:2][C:3]([CH2:17][F:18])([CH3:16])[C:4](=[O:15])[CH:5](Br)[O:6][C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1.N1C=[CH:22][N:21]=[N:20]1.[C:24](#[N:26])C>>[F:1][CH2:2][C:3]([CH2:17][F:18])([CH3:16])[C:4](=[O:15])[CH:5]([O:6][C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)[N:21]1[CH:22]=[N:26][CH:24]=[N:20]1参加物
4
反応条件
- 温度
- 50 °C
実験手順
190 g (0.557 mol) of 3,3-bisfluoromethyl-1-bromo-1-(4-chlorophenoxy)-butan-2-one and 90 g (1.3 mols) of triazole were introduced into 800 ml of acetonitrile, the mixture was heated at 50° C. for 5 hours, the solvent was distilled off under a waterpump vacuum, the residue was taken up in one liter of methylene chloride and washed twice with 1,000 ml of water each time, the organic phase was dried over sodium sulphate and the solvent was distilled off. The residue was taken up in 500 ml of diisopropyl ether and the precipitate was filtered off. The mother liquor was distilled. 130.5 g (71% of theory) of 3,3-bisfluoromethyl-1-(4-chlorophenoxy)-1-(1,2,4-triazol-1-yl)-butan-2-one of boiling point 160°-66° C./0.2 mm Hg were obtained. ##STR76##