Methanol → HCID 12249281、化合物

HRID 2198818ノート

反応式

HRID 2198818 の反応式
[O:1]=[C:2]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[CH2:14][C:15]([OH:17])=[O:16].S(=O)(=O)(O)O.[OH-].[Na+].[CH3:25]O>[O-]S([O-])(=O)=O.[Na+].[Na+]>[CH3:25][O:16][C:15](=[O:17])[CH2:14][CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:2]1=[O:1]

参加物

6

反応物 4

HCID 887MethanolHCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 317519Cyclododecaneaceticacid, 2-oxo-

生成物 1

HCID 12249281HCID 12249281、化合物収率 97%

試薬・触媒・溶媒 1

HCID 24436Sodium Sulfate触媒

実験手順

One hundred seventy-five grams (0.73 mol) of the ketomono acid from step 3 and 440 ml of methanol were refluxed with agitation for 3 hours with the addition of 7.3 gm of concentrated sulfuric acid. The cooled solution was neutralized with 50% sodium hydroxide solution and then methanol and water were completely removed. The residue contained, in addition to small amounts of salt (approximately 10 gm of Na2SO4), approximately 180 gm of ketomonoester (IX) (97% yield), which was further reacted in that form.

後処理

  1. custommethanol and water were completely removed

出典と根拠

ORDレコード
ord-f87eedfd9ec7431e8d515adf77301e2b
出典データセット
uspto-grants-1982_11
特許番号
US04360468

反応ノート

読み込み中…