Phenol → HCID 13055710、化合物

HRID 2198846ノート

反応式

HRID 2198846 の反応式
[CH:1]([N:4]1[CH2:7][CH:6]([O:8][CH2:9][O:10][CH3:11])[CH2:5]1)([CH3:3])[CH3:2].[C:12]1([OH:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[OH-].[Na+]>CCOCC>[O:18]([CH2:5][CH:6]([O:8][CH2:9][O:10][CH3:11])[CH2:7][NH:4][CH:1]([CH3:2])[CH3:3])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 996PhenolHCID 14798Sodium HydroxideHCID 205173143-(Methoxymethoxy)-1-(propan-2-yl)azetidine

生成物 1

HCID 13055710HCID 13055710、化合物収率 67%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
180 °C

実験手順

To a mixture of 1.6 parts of 1-iso-propyl-3-methoxymethoxyazetidine and 9.4 parts of phenol 0.5 part of sodium hydroxide was addded, and the mixture was heated at 180° C. for 6 hours. The reaction mixture was cooled and 100 parts of ether were added thereto. Excessive phenol was removed by extraction with 2 N-sodium hydroxide aqueous solution, and the remaining ether layer was washed in water and dried over anhydrous sodium sulfate. After distillation of ether, the residue was subjected to distillation to yield 1.6 parts of 1-phenoxy-2-methoxymethoxy-3-(iso-propylamino)-propane boiling at 146°-149° C. under 2 mm Hg. The yield was 67%.

後処理

  1. temperatureThe reaction mixture was cooled
  2. customExcessive phenol was removed by extraction with 2 N-sodium hydroxide aqueous solution
  3. washthe remaining ether layer was washed in water
  4. dry with materialdried over anhydrous sodium sulfate
  5. distillationAfter distillation of ether
  6. distillationthe residue was subjected to distillation

出典と根拠

ORDレコード
ord-2c1f4e08a2ae4f29958bfbdb7772391f
出典データセット
uspto-grants-1982_11
特許番号
US04360464

反応ノート

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