2-Azido-9-(2-hydroxyethoxymethyl)adenine → 2,6-Diamino-9-(2-hydroxyethoxymethyl)purine

HRID 2198906ノート

反応式

HRID 2198906 の反応式
[N:1]([C:4]1[N:12]=[C:11]2[C:7]([N:8]=[CH:9][N:10]2[CH2:13][O:14][CH2:15][CH2:16][OH:17])=[C:6]([NH2:18])[N:5]=1)=[N+]=[N-]>[Pd].C(O)C>[NH2:1][C:4]1[N:12]=[C:11]2[C:7]([N:8]=[CH:9][N:10]2[CH2:13][O:14][CH2:15][CH2:16][OH:17])=[C:6]([NH2:18])[N:5]=1

参加物

4

反応物 1

HCID 205176782-Azido-9-(2-hydroxyethoxymethyl)adenine

生成物 1

HCID 945882,6-Diamino-9-(2-hydroxyethoxymethyl)purine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 2-azido-9-(2-hydroxyethoxymethyl)adenine (0.41 g) and 10% palladium on charcoal (80 mg) in ethanol (41 ml) was shaken under hydrogen at 50 psi for 3.5 hours. The catalyst as removed by filtration through a celite pad and washed thoroughly with ethanol and water. The solvent was removed by evaporation under reduced pressure giving a quantitative yield (0.37 g) of nearly pure (one spot on TLC) 2-amino-9-(2-hydroxyethoxymethyl)adenine, m.p. 183°-184° C. after recrystallization from n-propanol.

後処理

  1. customThe catalyst as removed by filtration through a celite pad
  2. washwashed thoroughly with ethanol and water
  3. customThe solvent was removed by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-a7d5c9e7b2424d61b1ef51c8bfc53ace
出典データセット
uspto-grants-1982_11
特許番号
US04360522

反応ノート

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