Methyl iodide → 2-Amino-6-methylthio-9-(2-hydroxyethoxymethyl)purine

HRID 2198921ノート

反応式

HRID 2198921 の反応式
[OH:1][CH2:2][CH2:3][O:4][CH2:5][N:6]1[CH:14]=[N:13][C:12]2[C:11](=[S:15])[NH:10][C:9]([NH2:16])=[N:8][C:7]1=2.[CH3:17]I>CO>[NH2:16][C:9]1[N:8]=[C:7]2[C:12]([N:13]=[CH:14][N:6]2[CH2:5][O:4][CH2:3][CH2:2][OH:1])=[C:11]([S:15][CH3:17])[N:10]=1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 178508225HCID 178508225、化合物

生成物 1

HCID 205176832-Amino-6-methylthio-9-(2-hydroxyethoxymethyl)purine収率 38%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture 9-(2-Hydroxyethoxymethyl)thioguanine (0.7 g), methyl iodide (0.2 ml), Dowex HCO3- resin (1.7 g) and methanol (200 ml) was stirred overnight at room temperature. The resin was removed by filtration, washed with methanol and the combined filtration evaporated, and the residue recrystallized from isopropanol and then from acetone to give 2-amino-6-methylthio-9-(2-hydroxyethoxymethyl)purine, m.p. 188°-191° C. in 38% yield.

後処理

  1. customThe resin was removed by filtration
  2. washwashed with methanol
  3. filtrationthe combined filtration
  4. customevaporated
  5. customthe residue recrystallized from isopropanol

出典と根拠

ORDレコード
ord-5dbb13b2905a477dab4943214cc88b9f
出典データセット
uspto-grants-1982_11
特許番号
US04360522

反応ノート

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