Hydrazine hydrate (1:1) → 4-Methoxy-N-[2-nitro-4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]benzamide
反応式
O.[NH2:2][NH2:3].C[O:5][C:6](=O)[CH2:7][CH:8]([C:10](=O)[C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:27])[C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)=[C:13]([N+:28]([O-:30])=[O:29])[CH:12]=1)[CH3:9]>C(O)(=O)C>[CH3:9][CH:8]1[C:10]([C:11]2[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:27])[C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)=[C:13]([N+:28]([O-:30])=[O:29])[CH:12]=2)=[N:3][NH:2][C:6](=[O:5])[CH2:7]1参加物
4
実験手順
20 ml of 80% hydrazine hydrate were added dropwise to 150 ml of glacial acetic acid while stirring and ice cooling. After cooling, 10.7 gm of 3-[3-nitro-4-(4-methoxybenzoylamino)-benzoyl]-butyric acid methyl ester were added and the mixture was refluxed for 40 minutes. After cooling, 250 ml of ice water were added, and the precipitate formed was suction filtered and washed with ice water.