Morpholino(4-nitro-3-(trifluoromethyl)phenyl)methanone → (4-Amino-3-(trifluoromethyl)phenyl)(morpholino)methanone
反応式
[O:1]1[CH2:6][CH2:5][N:4]([C:7]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[C:11]([C:18]([F:21])([F:20])[F:19])[CH:10]=2)=[O:8])[CH2:3][CH2:2]1>C(O)C.[Pd]>[NH2:15][C:12]1[CH:13]=[CH:14][C:9]([C:7]([N:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)=[O:8])=[CH:10][C:11]=1[C:18]([F:21])([F:20])[F:19]参加物
4
実験手順
A mixture of EXAMPLE 144A (13 g) and Pd/C (1.3 g, 10%) in ethanol (300 mL) was stirred under hydrogen at room temperature for two days. The catalyst was filtered off and the solvent was evaporated to provide the final compound.
後処理
- filtrationThe catalyst was filtered off
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-607605d4353444b1a8ece2c5695ccfdf
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09359296B2
反応ノート
読み込み中…