1-Methanesulfonyl-3-nitro-5-trifluoromethylbenzene → 3-Methanesulfonyl-5-(trifluoromethyl)aniline

HRID 2200124ノート

反応式

HRID 2200124 の反応式
[CH3:1][S:2]([C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([N+:15]([O-])=O)[CH:6]=1)(=[O:4])=[O:3]>CO.[Pd]>[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([CH:8]=[C:9]([C:11]([F:12])([F:13])[F:14])[CH:10]=1)[NH2:15])(=[O:4])=[O:3]

参加物

4

反応物 1

HCID 684231001-Methanesulfonyl-3-nitro-5-trifluoromethylbenzene

生成物 1

HCID 592861463-Methanesulfonyl-5-(trifluoromethyl)aniline収率 73.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Stir the mixture of 1-(methylsulfonyl)-3-nitro-5-(trifluoromethyl)benzene (2 g, 7.43 mmol), Pd/C (10%, 500 mg) in methanol (100 mL) under hydrogen atmosphere at room temperature for 15 hrs. Filter off the solid and concentrate the filtrate under reduced pressure. Purify the residue with flash chromatography (silica gel, EtOAc:PE=1:5) to afford the desired product (1.3 g, 73%). MS: (M+23): 262.0.

後処理

  1. filtrationFilter off the solid
  2. concentrationconcentrate the filtrate under reduced pressure
  3. customPurify the residue with flash chromatography (silica gel, EtOAc:PE=1:5)

出典と根拠

ORDレコード
ord-ef311f5d17df41ff838e414a251bdca7
出典データセット
uspto-grants-2016_06
特許番号
US09359338B2

反応ノート

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