2-methoxy-N-(3-nitro-5-(trifluoromethyl)phenyl)acetamide → N-(3-amino-5-(trifluoromethyl)phenyl)-2-methoxyacetamide

HRID 2200140ノート

反応式

HRID 2200140 の反応式
[CH3:1][O:2][CH2:3][C:4]([NH:6][C:7]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[C:9]([N+:17]([O-])=O)[CH:8]=1)=[O:5]>CO.[Pd]>[NH2:17][C:9]1[CH:8]=[C:7]([NH:6][C:4](=[O:5])[CH2:3][O:2][CH3:1])[CH:12]=[C:11]([C:13]([F:15])([F:16])[F:14])[CH:10]=1

参加物

4

反応物 1

HCID 900201822-methoxy-N-(3-nitro-5-(trifluoromethyl)phenyl)acetamide

生成物 1

HCID 90020420N-(3-amino-5-(trifluoromethyl)phenyl)-2-methoxyacetamide収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Add Pd/C (10%, 30 mg) to the solution of 2-methoxy-N-(3-nitro-5-(trifluoromethyl)phenyl)acetamide (100 mg, 0.36 mmol) in methanol (6 mL), stir the mixture under hydrogen atmosphere at room temperature for 16 hrs. Filter off the solid, concentrate the filtrate under reduced pressure to yield the crude product (89 mg, 100%) which is used without further purification.

後処理

  1. filtrationFilter off the solid
  2. concentrationconcentrate the filtrate under reduced pressure

出典と根拠

ORDレコード
ord-b07614988f5e48d597e7a8a99a8c4906
出典データセット
uspto-grants-2016_06
特許番号
US09359338B2

反応ノート

読み込み中…