4-Fluoro-1-(3-nitro-5-(trifluoromethyl)phenyl)piperidine → 3-(4-Fluoropiperidin-1-yl)-5-(trifluoromethyl)aniline
反応式
[F:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[C:10]([N+:18]([O-])=O)[CH:9]=2)[CH2:4][CH2:3]1>CO.[Pd]>[F:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10]([CH:11]=[C:12]([C:14]([F:17])([F:15])[F:16])[CH:13]=2)[NH2:18])[CH2:4][CH2:3]1参加物
4
実験手順
Add Pd/C (10%, 70 mg) to the solution of 4-fluoro-1-(3-nitro-5-(trifluoromethyl)phenyl)piperidine (300 mg, 1.0 mmol) in methanol (10 mL), stir the mixture under hydrogen atmosphere for 16 hrs at room temperature. Filter and concentrate the filtrate to get the crude product (270 mg, 100%) which is used directly without further purification.
後処理
- filtrationFilter
- concentrationconcentrate the filtrate
出典と根拠
- ORDレコード
- ord-2f79a566dcc744149cf248499c1f9948
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09359338B2
反応ノート
読み込み中…