1-Methyl-4-[[3-nitro-5-(trifluoromethyl)phenyl]methyl]piperazine → 3-((4-Methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)aniline
反応式
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[C:11]([N+:19]([O-])=O)[CH:10]=2)[CH2:4][CH2:3]1>CO.[Pd]>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([CH:12]=[C:13]([C:15]([F:18])([F:16])[F:17])[CH:14]=2)[NH2:19])[CH2:4][CH2:3]1参加物
4
実験手順
Add Pd/C (10%, 200 mg) to the solution of 1-methyl-4-(3-nitro-5-(trifluoromethyl)benzyl)piperazine (812 mg, 2.68 mmol) in methanol (15 mL), flush with H2, stir under hydrogen atmosphere for 16 hrs at room temperature. Filter and concentrate the filtrate to give the crude product (732 mg, 100%). MS: (M+1): 273.0.
後処理
- customflush with H2
- filtrationFilter
- concentrationconcentrate the filtrate
出典と根拠
- ORDレコード
- ord-b5973325894f445c9038746304f113c1
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09359338B2
反応ノート
読み込み中…