HCID 89924447、化合物 → 1226160-70-8

HRID 2200353ノート

反応式

HRID 2200353 の反応式
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[CH2:10][C:9]1([CH3:22])[CH3:21])C1C=CC=CC=1>CO.C(OCC)(=O)C.[Pd]>[F:20][C:17]1[CH:16]=[CH:15][C:14]([N:11]2[CH2:12][CH2:13][NH:8][C:9]([CH3:22])([CH3:21])[CH2:10]2)=[CH:19][CH:18]=1

参加物

5

反応物 1

HCID 89924447HCID 89924447、化合物

生成物 1

HCID 572767191226160-70-8

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
50 °C

実験手順

To a stirred solution of 1-benzyl-4-(4-fluorophenyl)-2,2-dimethylpiperazine (4.5 g, 15.08 mmol) in methanol and ethyl acetate (5:1, 60 ml) at 25° C. was added 10% palladium on charcoal (1.605 g). The reaction mixture was stirred at 50° C. for 5 h. The progress of reaction was monitored by TLC. The reaction mixture was cooled to room temperature, filtered through a celite bed, washed with ethyl acetate (2×50 ml). The combined filtrate was concentrated under reduced pressure to obtain the title compound which was used in the next step without further purification.

後処理

  1. customThe progress of reaction
  2. temperatureThe reaction mixture was cooled to room temperature
  3. filtrationfiltered through a celite bed
  4. washwashed with ethyl acetate (2×50 ml)
  5. concentrationThe combined filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-cddfff64cb2a4d51a3df076ec01decaa
出典データセット
uspto-grants-2016_06
特許番号
US09359367B2

反応ノート

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