Methanol → Methyl (1S,3R)-3-aminocyclopentane-1-carboxylate
反応式
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][C@@H:5]([C:8]([OH:10])=[O:9])[CH2:4]1.S(Cl)(Cl)=O.[CH3:15]O>>[CH3:15][O:9][C:8]([C@H:5]1[CH2:6][CH2:7][C@@H:3]([NH2:2])[CH2:4]1)=[O:10]参加物
4
実験手順
To a solution of (1R,3S)-3-aminocyclopentanecarboxylic acid hydrochloride (2.5 g, 15.09 mmol) in dry methanol (10 ml) under N2 at 0° C. was added thionyl chloride (5.51 ml, 75 mmol) dropwise. The reaction mixture was slowly warmed to room temperature and stirred overnight. The reaction was concentrated in vacuo. The resultant residue was washed with anhydrous diethyl ether (3×30 ml) and dried under high vacuum to afford of (1S,3R)-3-aminocyclopentanecarboxylic acid methyl ester (2.65 g 98%) as the hydrochloride salt that was used in a subsequent reaction without purification.
後処理
- concentrationThe reaction was concentrated in vacuo
- washThe resultant residue was washed with anhydrous diethyl ether (3×30 ml)
- customdried under high vacuum
出典と根拠
- ORDレコード
- ord-6353dbb7a62d442189c700f6d6bd7b85
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09359367B2
反応ノート
読み込み中…