Water → (R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)propanamide
反応式
[Cl:1][C:2]1[C:3]([C:9]#[N:10])=[N:4][CH:5]=[C:6](Cl)[N:7]=1.Cl.[NH2:12][C@@H:13]([C:15]([NH2:17])=[O:16])[CH3:14].CCN(C(C)C)C(C)C.O>CN1C(=O)CCC1.CCOC(C)=O>[Cl:1][C:2]1[N:7]=[C:6]([NH:12][C@H:13]([CH3:14])[C:15]([NH2:17])=[O:16])[CH:5]=[N:4][C:3]=1[C:9]#[N:10]参加物
7
実験手順
A solution of 3,5-dichloropyrazine-2-carbonitrile (150 mg, 0.862 mmol), D-alaninamide hydrochloride (107 mg, 0.858 mmol) and DIEA (0.400 mL, 2.30 mmol) in NMP (4 mL) was stirred at room temperature for 20 h. Water and EtOAc were added. Organic phase was separated, dried over Na2SO4, concentrated in vacuo to give (R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)propanamide as an oil (194 mg).
後処理
- customOrganic phase was separated
- dry with materialdried over Na2SO4
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-1074a1a6f609496989432d1b8c87a0b6
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09359308B2
反応ノート
読み込み中…