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4-(4-Nitrophenyl)pyridine → 4-(Pyridin-4-yl)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(4-Nitrophenyl)pyridine | HCID 259219 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-(Pyridin-4-yl)aniline | HCID 1512654 | 90.5% |
反応手順
A mixture of 4-(4-nitrophenyl)pyridine (274 mg, 1.37 mmol) and Pd—C (10%, 80 mg) in MeOH (10 mL) was hydrogenated under balloon H2 for 20 h. The mixture was then filtered through celite. The filtrate was concentrated in vacuo to give 4-(pyridin-4-yl)aniline as a solid (211 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09359308B2 |
| 出典データセット | uspto-grants-2016_06 |
| ORD ID | ord-7a25cde2b5b54a6f9767270dfdca7728 |
| 出典メモ | uspto-grants-2016_06 |