Acetic Acid → HCID 86685598、化合物

HRID 2200481ノート

反応式

HRID 2200481 の反応式
[C:1]([C:3]1[N:4]=[CH:5][C:6]([NH:20][C:21]2([C:25]([NH2:27])=[O:26])[CH2:24][CH2:23][CH2:22]2)=[N:7][C:8]=1[NH:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[N:16]=[CH:15][CH:14]=[CH:13]2)#[N:2].[OH-].[Na+].OO.CC(O)=[O:34]>CCO.CS(C)=O>[C:25]([C:21]1([NH:20][C:6]2[N:7]=[C:8]([NH:9][C:10]3[CH:11]=[C:12]4[C:17](=[CH:18][CH:19]=3)[N:16]=[CH:15][CH:14]=[CH:13]4)[C:3]([C:1]([NH2:2])=[O:34])=[N:4][CH:5]=2)[CH2:24][CH2:23][CH2:22]1)(=[O:26])[NH2:27]

参加物

7

反応物 4

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 86685597HCID 86685597、化合物

生成物 1

HCID 86685598HCID 86685598、化合物

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 702Ethanol溶媒

実験手順

The compound 1-(5-cyano-6-(quinolin-6-ylamino)pyrazin-2-ylamino)cyclobutanecarboxamide (10 mg, 0.028 mmol) was dissolved in EtOH (1 mL) and DMSO (0.5 mL), aq. 1N NaOH (0.50 mL) and aq. H2O2 (30%, 0.50 mL) were added. The mixture was stirred at room temperature for 15 min. HOAc (0.1 mL) was added. The mixture was then concentrated in vacuo. The residue was purified by HPLC to give the titled compound (7 mg). MS378.2 (M+H); UV 204.8, 267.7, 297.8, 358.5 nm; t 0.423 min.

後処理

  1. concentrationThe mixture was then concentrated in vacuo
  2. customThe residue was purified by HPLC

出典と根拠

ORDレコード
ord-d9486f2b200944c496bdf1234c249831
出典データセット
uspto-grants-2016_06
特許番号
US09359308B2

反応ノート

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