Sodium borohydride → 3-(6-(4-(4-Chlorothiazol-2-yl)-4-hydroxybutyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

HRID 2201214ノート

反応式

HRID 2201214 の反応式
[BH4-].[Na+].[Cl:3][C:4]1[N:5]=[C:6]([C:9](=[O:34])[CH2:10][CH2:11][CH2:12][N:13]2[C:21]([C:22]3[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=3)[C:25]#[N:26])=[C:20]3[C:15]([N:16]([CH3:33])[C:17](=[O:32])[N:18]([CH3:31])[C:19]3=[O:30])=[CH:14]2)[S:7][CH:8]=1>C(O)C>[Cl:3][C:4]1[N:5]=[C:6]([CH:9]([OH:34])[CH2:10][CH2:11][CH2:12][N:13]2[C:21]([C:22]3[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=3)[C:25]#[N:26])=[C:20]3[C:15]([N:16]([CH3:33])[C:17](=[O:32])[N:18]([CH3:31])[C:19]3=[O:30])=[CH:14]2)[S:7][CH:8]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 867234533-(6-(4-(4-Chlorothiazol-2-yl)-4-oxobutyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

生成物 1

HCID 867234543-(6-(4-(4-Chlorothiazol-2-yl)-4-hydroxybutyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
0 °C

実験手順

Sodium borohydride (0.606 g, 16.03 mmol) was added portionwise to a suspension of 3-(6-(4-(4-chlorothiazol-2-yl)-4-oxobutyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile (2.5 g, 5.34 mmol) in ethanol (53.4 mL) at 0° C. The reaction mixture was stirred for 15 minutes at 0° C., the quenched with water (25 mL) and extracted with DCM (3×50 mL). The combined organic fractions were dried over magnesium sulfate and evaporated under reduced pressure to afford the title compound.

後処理

  1. customthe quenched with water (25 mL)
  2. extractionextracted with DCM (3×50 mL)
  3. dry with materialThe combined organic fractions were dried over magnesium sulfate
  4. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-cb5f337bcaa4468798ba3b00614be78d
出典データセット
uspto-grants-2016_06
特許番号
US09359381B2

反応ノート

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