Dichloromethane → (1-Chloro-3-((4-methoxybenzyl)oxy)propan-2-yl)(trityl)sulfane

HRID 2201224ノート

反応式

HRID 2201224 の反応式
[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6]([CH2:7][O:8][CH2:9][CH:10]2[CH2:12][S:11]2)=[CH:5][CH:4]=1.[C:15](Cl)([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[Cl:35]CCl>>[Cl:35][CH2:12][CH:10]([S:11][C:15]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[CH2:9][O:8][CH2:7][C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:14][CH:13]=1

参加物

4

反応物 3

HCID 6344DichloromethaneHCID 6456Trityl chlorideHCID 867234592-(((4-Methoxybenzyl)oxy)methyl)thiirane

生成物 1

HCID 86723460(1-Chloro-3-((4-methoxybenzyl)oxy)propan-2-yl)(trityl)sulfane

実験手順

2-(((4-Methoxybenzyl)oxy)methyl)thiirane (496 mg, 2.359 mmol) was added to a solution of trityl chloride (598 mg, 2.144 mmol) in dichloromethane (10 mL). The mixture was stirred at room temperature for 16 hours, then evaporated under vacuum. Purification by chromatography on silica, eluting with 0-5% EtOAc/hexane, gave a crude material which was triturated with methanol to afford the title compound.

後処理

  1. customevaporated under vacuum
  2. customPurification by chromatography on silica
  3. washeluting with 0-5% EtOAc/hexane
  4. customgave a crude material which
  5. customwas triturated with methanol

出典と根拠

ORDレコード
ord-3134e65ea8b04e1faec6a6ae2f61234e
出典データセット
uspto-grants-2016_06
特許番号
US09359381B2

反応ノート

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