Hydrochloric Acid → (Spiro(2.5)octan-6-yl)methanamine hydrochloride
反応式
[CH2:1]1[C:3]2([CH2:8][CH2:7][CH:6]([CH2:9][NH:10]C(=O)OCC3C=CC=CC=3)[CH2:5][CH2:4]2)[CH2:2]1.[ClH:21]>CO.[Pd]>[ClH:21].[CH2:2]1[C:3]2([CH2:8][CH2:7][CH:6]([CH2:9][NH2:10])[CH2:5][CH2:4]2)[CH2:1]1参加物
5
実験手順
Compound 8-5 (2.85 g, 10.4 mmol) was dissolved in 30 mL of methanol, added 0.2 g of palladium on carbon and 1 mL of concentrated hydrochloric acid, and subjected to catalytic hydrogenation reaction overnight and filtered to remove insolubles, then concentrated to give Compound 8-6 (1.8 g, yield 98.5%).
後処理
- customsubjected to catalytic hydrogenation reaction overnight
- filtrationfiltered
- customto remove insolubles
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-8d0342622ee946f08d7a093ce57df40b
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09365499B2
反応ノート
読み込み中…