Thionyl Chloride → 2,6-Dichloro-4-(methylcarbamoyl)benzoyl chloride

HRID 2201780ノート

反応式

HRID 2201780 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:14])[NH:12][CH3:13])[CH:8]=[C:7]([Cl:15])[C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:18])=O>ClCCl>[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:14])[NH:12][CH3:13])[CH:8]=[C:7]([Cl:15])[C:3]=1[C:4]([Cl:18])=[O:5]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 710616332,6-Dichloro-4-(methylcarbamoyl)benzoic acid

生成物 1

HCID 867206232,6-Dichloro-4-(methylcarbamoyl)benzoyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
50 °C

実験手順

A mixture of 2,6-dichloro-4-(methylcarbamoyl)benzoic acid (400 mg, 1.6 mmol) and thionyl chloride (1.91 g, 16 mmol) in dichloromethane (10 mL) was stirred at 50° C. for 5 hours. The reaction mixture was concentrated under rotary evaporator and used as such for next step.

後処理

  1. concentrationThe reaction mixture was concentrated under rotary evaporator

出典と根拠

ORDレコード
ord-c721ab444c494f1181f3d9ce3afef53d
出典データセット
uspto-grants-2016_06
特許番号
US09364466B2

反応ノート

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