Ethyl 2-(4-bromophenyl)acrylate → HCID 59238305、化合物

HRID 220191

反応式

HRID 220191 の反応式
[CH2:1]([N:3]([CH2:9][CH3:10])[CH:4]1[CH2:8][CH2:7][NH:6][CH2:5]1)[CH3:2].[CH2:11]([O:13][C:14](=[O:24])[C:15]([C:17]1[CH:22]=[CH:21][C:20]([Br:23])=[CH:19][CH:18]=1)=[CH2:16])[CH3:12]>C1COCC1>[CH2:11]([O:13][C:14](=[O:24])[CH:15]([C:17]1[CH:18]=[CH:19][C:20]([Br:23])=[CH:21][CH:22]=1)[CH2:16][N:6]1[CH2:7][CH2:8][CH:4]([N:3]([CH2:9][CH3:10])[CH2:1][CH3:2])[CH2:5]1)[CH3:12]

参加物

4

反応物 2

HCID 11470828Ethyl 2-(4-bromophenyl)acrylateHCID 199619953-(Diethylamino)pyrrolidine

生成物 1

HCID 59238305HCID 59238305、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of diethyl-pyrrolidin-3-yl-amine (0.685 g, 6 mmol) in THF (10 mL) was added 2-(4-bromo-phenyl)-acrylic acid ethyl ester (1.27 g, 5 mmol) dropwise in THF at 0 degrees Celsius. Then the mixture was stirred at room temperature for 1 h and concentrated in vacuo. The residue was dissolved in EtOAc (30 mL), washed with water (20 mL×2), brine, dried over Na2SO4, filtered and evaporated. The obtained oil was used directly without further purification. MS: calc'd 397 (MH+), exp 397 (MH+).

後処理

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue was dissolved in EtOAc (30 mL)
  3. washwashed with water (20 mL×2), brine
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customevaporated
  7. customThe obtained oil was used directly without further purification

出典と根拠

ORDレコード
ord-d6f463bfc9244d15b6edf63ba213c07a
出典データセット
uspto-grants-2012_06
特許番号
US08202866B2

関連ノート

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